Clinical calculator

eGFR by CKD-EPI Creatinine Equation (2021) in Adults

A browser-only educational calculator for race-free CKD-EPI 2021 eGFRcr. Information entered on this page is not saved or stored by RPHprep.

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RPHprep provides educational exam-preparation content only. It is not medical advice, legal advice, or a substitute for professional judgment. Users should consult current Canadian laws, standards, guidelines, product monographs, and official regulatory resources.

Information you record on this page is not saved or stored. Print or send before leaving this page to avoid losing the information you enter.

Only digits 0 to 9 and a single decimal point are acceptable as numeric inputs. Attempted input of other characters into a numeric field may lead to an incorrect result.

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CKD-EPI creatinine inputs

Equation

eGFRcr = 142 * min(SCr/kappa, 1)^alpha * max(SCr/kappa, 1)^-1.2 * 0.9938^Age * SexFactor

BSA = 0.007184 * Height^0.725 * Weight^0.425

Sex

Optional BSA de-indexing inputs

Enter both height and weight to estimate eGFRcr without normalization to BSA of 1.73 m2.

Calculation details and notes

For females, the calculator uses SexFactor 1.012, alpha -0.241, and kappa 0.7. For males, it uses SexFactor 1, alpha -0.302, and kappa 0.9.

eGFRcr is an estimate of kidney function when kidney function is stable. Normalized eGFR uses a BSA of 1.73 m2 to support comparison across body sizes.

For medication-related decision making, references may use eGFR without normalization to BSA in patients with body surface areas substantially lower or higher than 1.73 m2.

eGFR values calculated using MDRD or CKD-EPI equations should not be used interchangeably with Cockcroft-Gault creatinine clearance values for drug dosage calculation or adjustment.

Creatinine-based estimates may need confirmation when muscle mass, diet, or medicines affect creatinine production or secretion.

References

  1. Inker LA, Eneanya ND, Coresh J, et al. New creatinine- and cystatin C-based equations to estimate GFR without race. N Engl J Med. 2021;385(19):1737-1749. Source
  2. St Peter WL, Bzowyckyj AS, Anderson-Haag T, et al. Moving forward from Cockcroft-Gault creatinine clearance to race-free estimated glomerular filtration rate. Am J Health Syst Pharm. 2025;82(12):644-659. Source
  3. Du Bois D, Du Bois EF. A formula to estimate the approximate surface area if height and weight be known. Arch Intern Med. 1916;17:863.